Elias Argyris
Associate Professor
Science, Technology, Engineering & Mathematics
Contact Information
Downingtown100 Bond Drive
Downingtown, PA 19335
484-237-6200
Room Number: 214
Phone: 484-237-6232
Contact Faculty
Born and raised in Greece. Educated in Greece, Bulgaria and USA. Dedicated my life to BioMedical Research and Education. Passionate about LIFE, SCIENCE, MUSIC and POLITICS. Question Everything! Courses Taught: BIO150, BIO151, BIO230
Degrees
- Ph.D. in Molecular Genetics
- M.Sci. in Biochemistry/Clinical Chemistry
Papers
- Microarray analysis to examine glycan-related gene expression in primary human cells infected with HIV-1
- Novel Proteoglycan-related Molecular Targets in HIV-1 infection of Primary Human Macrophages: Implications for Neuropathogenesis
- The Interferon-induced expression of APOBEC3G in human blood brain barrier exerts a potent intrinsic immunity to block HIV-1 ent
- Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes.
- Cell associated heparan sulfate proteoglycans are involved in HIV-1 attachment and entry into primary human astrocytes
- Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displaye
- Expression of APOBEC family members of cytidine deaminases in the Central Nervous System
- Inhibition of Natural Endogenous Reverse Transcription of Human and Non-Human Primate Lentiviruses: Potential for Development of
- Caffeine Inhibits HIV-1 Transduction of Non-dividing Cells.
- IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally sup
- Inhibition of HIV-1 Replication by the ATR and ATM Inhibitor Caffeine and Caffeine-related Methylxanthines
- HIV-1 Vif versus APOBEC3G: newly appreciated warriors in the ancient battle between virus and host.
- The Perlecan Heparan Sulfate Proteoglycan Mediates Cellular Uptake of HIV-1 Tat through a pathway responsible for biological act
- HIV-1 Enters Primary Human Brain Microvascular Endothelial Cells by a Mechanism Involving Cell-Surface proteoglycans Independent
- The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.
- Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity.
- Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme
- The connection domain is implicated in metalloporphyrin binding and inhibition of HIV Reverse Transcriptase.
- Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT).
- Genetic Markers in Beryllium Hypersensitivity.
- Identification of DRB1 allele (DRB1*1316) with aspartate at position 86: evolutionary considerations and functional implications
- New DRB1*1120 allele; another example of the transition between the DR11 and DR13 families of alleles.
- Identification of HLA-DRB1*1114 by oligonucleotide typing and DNA sequencing.
- Structural Basis for MHC Linked Susceptibility to Autoimmunity: Charged Residues of a Single MHC Binding Pocket Confer Selective
- DNA-based HLA typing of Nonhematopoietic Tissue used to select the Marrow Transplant donor for successful treatment of transfusi
- Identification of a new HLA-DPB1 allele (DPB1*5101) by oligotyping and nucleotide sequencing.
Academic Biography
Teaching Experience: Biology, Microbiology, Pathogenesis of Disease, Infectious Diseases, Anatomy Physiology, Immunology, Genetics, Molecular Biology, Human Nutrition, Biotechnology, Biology of Cancer, Neuroscience, HIV-1 Neuropathogenesis. Expertise in: Molecular Virology and Microbiology: HIV-1, HIV-RT, NeuroScience-NeuroAIDS, Molecular Genetics and Prenatal Diagnosis (beta-thalassaemia, cystic fibrosis and other inherited diseases). Immunogenetics: MHC, HLAs, Autoimmune Diseases, Antigen Presentation, Molecular Biology, Protein-Protein Interactions (Phage-Peptide Libraries), Protein-Drug Interactions. Drug development. Published over 20 scientific research articles and reviews in prestigious biomedical journals. Upon invitation, presented research work by means of poster and oral presentations (over 35) in numerous national and international conferences and symposia. Oversaw and implemented various academic administrative and financial projects as head, president, or board member of numerous academic committees, scientific organizations and centers. Planned and organized conferences, seminars and academic symposia. Recipient of several federal, national and international, and foundation awards and grants. Bilingual in English and Greek, fluent in Bulgarian. US Citizen. EDUCATION: B.S.-M.Sc., Biochemistry/Clinical Chemistry, University of Sofia – Bulgaria, 1981-1987 Ph.D., Clinical Molecular Genetics, University of Sofia-Medical Academy of Sofia Bulgaria,1987-1991
Theoretical Approach, Experience, and Temperament
EDUCATION: B.S.-M.Sc.: Biochemistry/Clinical Chemistry, University of Sofia – Bulgaria, 1981-1987 Ph.D., Clinical Molecular Genetics, University of Sofia-Medical Academy of Sofia Bulgaria,1987-1991 PREGRADUATE AND POSTGRADUATE TRAINING AND EMPLOYMENT: Predoctoral Visiting Fellow Laboratory of Molecular Genetics, Institut für Humangenetic der Universitat, Münster-Germany (Supervisor: Horst J, M.D., Kalaydjieva L, M.D.), February 1989 Predoctoral Visiting Fellow Laboratory of Prenatal Diagnosis of beta-Thalassaemia, "Laikon" General Hospital First Department of Medicine University of Athens School of Medicine, Greece, (Supervisor: Loukopoulos D, M.D), June-August 1990 Greek Army Medical Service, 1991-1992 Consultant ORGANON TEKNIKA HELLAS-AKZO, Greece 1992-1993 Post-doctoral fellow, Dept. of Pathology and Laboratory Medicine, University of Pennsylvania-Medical Center, Philadelphia, PA. (Supervisor: D. Monos, Ph.D), 1993-1996 Post-doctoral fellow, Dept. of Microbiology, University of Pennsylvania-Medical School, Philadelphia, PA. (Supervisor: Y. Paterson, Ph.D), 1996-June 1998 Research Associate, Dept. of Microbiology, University of Pennsylvania-Medical School, Philadelphia, PA, (Supervisor: Y. Paterson, Ph.D) June 1998-May 2001 Visiting Fellow, Dept. of Medicine, division of Infectious Diseases, Center for AIDS Research (CFAR), Case Western Reserve University (CWRU), Cleveland, OH, (Supervisor: S. Le Grice, Ph.D), February 1999 Senior Research Associate, Dept. of Medicine, Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA, (Supervisors: R. J. Pomerantz, M.D., H. Zhang, Ph.D., K. Jon Williams, M.D., M. Schnell, Ph.D) May 2001- February 2007 Assistant Professor of Medicine (Tenure Track), Dept. of Medicine, Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA. March 2007-December 2010. Adjunct Professor, Jefferson Graduate School of Biomedical Sciences (JGSBS), Thomas Jefferson University, Philadelphia, PA. December 2010-present Adjunct Professor, Dept. of Biology, Chestnut Hill College, Philadelphia, PA. August 2011-2014 Adjunct Professor, Philadelphia University, College of Sciences, Health and the Liberal Arts, Dept. of Biology, Philadelphia, July 2014 –August 2014 Visiting Assistant Professor, Philadelphia University, College of Sciences, Health and the Liberal Arts, Dept. of Biology, Philadelphia, August 2014 –August 2015 Adjunct Professor, Philadelphia University, College of Sciences, Health and the Liberal Arts, Dept. of Biology, Philadelphia, August 2015 –2017 Adjunct Professor, Dept. of Biology, Rosemont College, Rosemont, PA, 19010, August 2015 – 2017 Adjunct Professor, STEM, Delaware County Community College (DCCC), July 2016 – August 2017 Subject Matter Expert (SME) Microbiology (Part-Time), Western Governor’s University (WGU), Online Degree Programs, July 2016-September 2016 Adjunct Professor, Temple University – School of Pharmacy, May 2017 – present Assistant Professor, STEM, Delaware County Community College (DCCC), August 2017 – June 2023 TENURED ASSOCIATE PROFESSOR, STEM, DCCC, JULY 2023-CURRENT
Scholarly Interests
- BioMedical Research and Education/Teaching are vitally and inseparably linked.
- Human and Viral Molecular Genetics and Environment.
