Elias Argyris

Associate Professor of Biology

Ph.D.

M.Sci.

Dedicated my life to BioMedical Research and Education.

Downingtown, Rm 214 100 Bond Drive, Downingtown, PA 19335

Phone 484-237-6232

Email eargyris@dccc.edu

Education

B.S. – Biochemistry/Clinical Chemistry, University of Sofia – Bulgaria

M.Sc. – Biochemistry/Clinical Chemistry, University of Sofia – Bulgaria

Ph.D., Clinical Molecular Genetics, University of Sofia-Medical Academy of Sofia Bulgaria

Personal Introduction

Born and raised in Greece. Educated in Greece, Bulgaria and the USA. Passionate about life, science, music and politics. Question Everything!

Courses Taught: BIO150, BIO151, BIO230

Academic Biography

Teaching Experience: Biology, Microbiology, Pathogenesis of Disease, Infectious Diseases, Anatomy Physiology, Immunology, Genetics, Molecular Biology, Human Nutrition, Biotechnology, Biology of Cancer, Neuroscience, HIV-1 Neuropathogenesis.

Expertise in: Molecular Virology and Microbiology: HIV-1, HIV-RT, NeuroScience-NeuroAIDS, Molecular Genetics and Prenatal Diagnosis (beta-thalassaemia, cystic fibrosis and other inherited diseases). Immunogenetics: MHC, HLAs, Autoimmune Diseases, Antigen Presentation, Molecular Biology, Protein-Protein Interactions (Phage-Peptide Libraries), Protein-Drug Interactions. Drug development.

Published over 20 scientific research articles and reviews in prestigious biomedical journals. Upon invitation, presented research work by means of poster and oral presentations (over 35) in numerous national and international conferences and symposia.

Oversaw and implemented various academic administrative and financial projects as head, president, or board member of numerous academic committees, scientific organizations and centers.
Planned and organized conferences, seminars and academic symposia. Recipient of several federal, national and international, and foundation awards and grants.

Bilingual in English and Greek, fluent in Bulgarian. US Citizen.

Scholarly Interests

BioMedical Research and Education/Teaching are vitally and inseparably linked.
Human and Viral Molecular Genetics and Environment.

Scholarly Papers

Microarray analysis to examine glycan-related gene expression in primary human cells infected with HIV-1

Novel Proteoglycan-related Molecular Targets in HIV-1 infection of Primary Human Macrophages: Implications for Neuropathogenesis

The Interferon-induced expression of APOBEC3G in human blood brain barrier exerts a potent intrinsic immunity to block HIV-1 ent

Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes.

Cell associated heparan sulfate proteoglycans are involved in HIV-1 attachment and entry into primary human astrocytes

Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displaye

Expression of APOBEC family members of cytidine deaminases in the Central Nervous System

Inhibition of Natural Endogenous Reverse Transcription of Human and Non-Human Primate Lentiviruses: Potential for Development of

Caffeine Inhibits HIV-1 Transduction of Non-dividing Cells.

IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally sup

Inhibition of HIV-1 Replication by the ATR and ATM Inhibitor Caffeine and Caffeine-related Methylxanthines

HIV-1 Vif versus APOBEC3G: newly appreciated warriors in the ancient battle between virus and host.

The Perlecan Heparan Sulfate Proteoglycan Mediates Cellular Uptake of HIV-1 Tat through a pathway responsible for biological act

HIV-1 Enters Primary Human Brain Microvascular Endothelial Cells by a Mechanism Involving Cell-Surface proteoglycans Independent

The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.

Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity.

Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme

The connection domain is implicated in metalloporphyrin binding and inhibition of HIV Reverse Transcriptase.

Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT).

Genetic Markers in Beryllium Hypersensitivity.

Identification of DRB1 allele (DRB1*1316) with aspartate at position 86: evolutionary considerations and functional implications

New DRB1*1120 allele; another example of the transition between the DR11 and DR13 families of alleles.

Identification of HLA-DRB1*1114 by oligonucleotide typing and DNA sequencing.

Structural Basis for MHC Linked Susceptibility to Autoimmunity: Charged Residues of a Single MHC Binding Pocket Confer Selective

DNA-based HLA typing of Nonhematopoietic Tissue used to select the Marrow Transplant donor for successful treatment of transfusi

Identification of a new HLA-DPB1 allele (DPB1*5101) by oligotyping and nucleotide sequencing.